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Stress Diet

Bad news

chic @ s. O good, we know that everything depends (Pau Dones said it with music before all his songs started to sound the same). I know they still are not even in spring and it's a little early to start worrying about the PROOF OF BIKINI / SWIMSUIT / TANGA / FARDAHUEVOS (I will not feel offended anyone or not included) but if any of you are thinking on dieting here's the bad news (in case you did not know yet.) Diets do not work.

better than they put salsa.

Not to mention those lightning diets that promise a wasp waist in 0.3 days without exercise (ha!) And eating 3 times a day in Mr. McDonald. I refer in general to so-called calorie restriction, or reduce the number / energy content of food a person eats to lose weight. There are many reasons why you might say that a diet does not work from blame lack of willpower to keep it as the so-called yo-yo effect or rebound which not long after recovering from a diet not only lost but also doubled. But Science tries to find answers beyond the obvious. We are the result of the interaction between our genes / biology and environment / environment, and of course this extends to our brain. Dieting changes your brain, change the way we face the stress and given that one way of dealing with stress is spoiling our pleasure centers, it is not surprising that we end up giving us chocolate and returning to the starting point .

dieting mice show higher stress levels. (A) Levels of corticosterone (B) Immobility in the suspension test. Adlib (food choice) RSTR (either restricted or diet)

But look at what our parents teach us about diet mousy. In an article recently published in Journal of Neuroscience Pankevich Diane et al. the researchers placed a group of mice "in plan" (caloric restriction) while another group could eat ad libitum or as much as they want in 3 weeks, after which the mice a diet had lost 10% of their initial weight becomes the average of what people lose when on a diet (a person lose 80 kilos an average of 8 kilos ...) and then measured a number of things. First, levels of stress. For that took blood samples from both groups of mice subjected to a slightly stressful, at least for a mouse (to be stuffed into a tube with reduced mobility. Similar to the feeling of being stuck in an fMRI scanner that also off-putting to some) and measured levels of corticosterone , a hormone associated with stress-in humans this role of "stress hormone" cortisol represents the - and found that although both groups increased their production corticosterone in response to the stress of "Trapped" (actually they can still move a little) diet mice responded much more intensely to stress. Another way to measure stress and how to react to this is the tail suspension test (literal translation but horrible ea! At least leaves little doubt), this test typically used to test new drugs efficiency cogeneration antidepressant (even after the transfer to humans is not usually too efficient) so that a passive reaction is associated with pro-depressive symptoms and vice versa. And this type of response was the one found in a majority in the mice on a diet, so it would seem to be on a diet (the least in mice) not only makes you more susceptible to stress but also more vulnerable to depression.

FLC appears here with their initials in English CRH

order to explain the origin of changes in the stress response the authors looked for changes in the expression of corticotropin releasing factor ( FLC) which regulates the expression of corticosterone in various brain regions and found differences between control mice and those put on a diet during and after allowing back to eating normally. The diet group had lower levels of FLC to the control group and this difference remained even after returning to "normal" diet.

Let us set aside for an advanced class of Biology / Molecular Genetics. The cell has several ways to control the levels of a protein, a protein act once already and others act by regulating their production or level of expression of the genes that encode them. Whether this level as the other consists of a multitude of mechanisms, but what interests us today is DNA methylation. The pattern of methylation is one of the calls epigenetic changes that are very fashionable lately among (if the surface we are) because they are changes on the expression of long duration, modified by the influence of source (experience, education or in this case the diet), not encoded by the sequence itself and even inheritable if they occur in germ cells (or gametes).

Now that we know what methylation is not surprised to learn that they also found that methylation-associated gene encoding FLC was also reduced in mice during and after diet compared to control. So that we understand, this means that the diet permanently changed the cellular machinery that controls the manner in which the mice were faced with stress. So the researchers decided to go a step further and see what happens when really stressed mice (something like a Wall Street Yupie a day of losses on the stock) are able to stick a feast of fat meal (this Once evoke the image of a Currywurst mit Pommes , so integration) and you can imagine the result. Our poor friends stressed and post-diet put the boots (although it could have been worse if the stress levels have been inflicted on the poor really like Yupie). Illustrating a of the possible causes of the rebound effect observed in humans.

good news. Well, two. The first is we are not mice and possibly some of the findings of the article can not be extrapolated (the diet is not depressed per se, since weight loss is seen as a victory and benefits are added) and the second is that there are more ways to lose weight by limiting the intake: Move! also the bonus that will reduce your stress levels.

Stress is a part of our lives so we better do to the idea and find the best way to deal with, I suggest you throw a look at the following article to learn more about the neurobiology of stress. To relajaos after this long article, I suggest you do like me and visit a while the sauna / pool / spa but remember any of this:

For more scary things visit: why you're fat.